Clinical outcome after SVR: Veterans Affairs

Clinical outcome after SVR: Veterans Affairs
CACOUB L, AASLD 2017, Abs. 78

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Systematic literature review

  • Random-effect model meta-analyses
  • Strength of evidence was evaluated using the GRADE system

Results

  • Data were extracted from a total of 48 identified studies
  • SVR was associated with:
    • reduced extrahepatic mortality (vs no SVR, OR = 0.44 [95% CI = 0.28-0.67])
    • higher complete remissions in patients with cryoglobulinemia vasculitis (OR = 20.76 [6.73-64.05])
    • higher objective response in malignant B-cell lymphoproliferative diseases (OR = 6.49 [2.02-20.85])
    • reduced insulin resistance at follow-up (OR = 0.42 [0.33-0.53])
    • a significant protective effect on the incidence of diabetes (OR = 0.34 [0.21-0.56])

Limitations

  • Lack of randomised data comparing SVR versus non-SVR patients for the relevant extrahepatic indications attenuated these analyses.